England U-21 manager Peter Taylor, who is also Hull City boss, will pick a side based of the best young players from outside the Premiership.
And Tilson will act as his assistant for the game, which will be played at the KC Stadium.
Tilson said: "It's a massive surprise for me but it is going to be a huge experience.
"I get on well with Peter Taylor. He could have chosen many others, but it will give me a great opportunity to see what goes on at international level.
"I might have a word in his ear though and point him in the direction of a few Southend and League One players."