Events at the game affect Scunthorpe - if United match Forest's result then the former European champions cannot catch the Iron.
Tyson suffered a knee injury during Easter Monday's 1-1 draw with Rotherham, with the club waiting to find out whether he can play again this season.
The 24-year-old had surgery earlier in the season for knee ligament damage.
"It is far too early to say how long Nathan might be out of action - but it is certainly not looking good for the weekend," said Forest boss Colin Calderwood.
"We will just have to give the knee a couple of days to settle down before we can really assess the damage."