Five players are suffering from the virus, along with manager Ian Atkins, meaning they may have a substitutes bench consisting entirely of YTs.
On top of the virus, they also have four players out injured.
Atkins said: "It's going through the whole camp. "A lot of players are struggling - we are down to less than the bare bones.
"We've got the doctor down and he's taking a look at the situation. But if we're short on players to face Southend there's nothing we can do."