Scunthorpe grabbed a 90th-minute winner thanks to leading scorer Billy Sharp against a Blackpool side which failed to muster a single shot on target.
The end result was one the Iron deserved after they totally dominated the second half, thanks to the inspiring work of Andy Keogh and the speed and assurance of Cleveland Taylor.
Blackpool lacked any real quality, although keeper Lee Jones had an excellent game and skipper Peter Clarke was dominant at the back, with Mark Joseph also having a solid game.
The match lacked any real sparkle in the opening 17 minutes, but then Scunthorpe burst into action. The move was initiated by Sharp setting Marcus Williams away on the right and when his cross came over the young striker stooped low to head wide.
Blackpool retaliated with midfielder Rory Prendergast firing in a shot that was well off target.
Sharp was soon threatening again for the Iron. He was given an excellent ball by Keogh, but finished by driving wide from a good position.
Ciaran Donnelly and Keigan Parker worked a good opening at the other end but the final effort ended up in Tommy Evans' hands without causing any undue problems.
Scunthorpe skipper Andrew Cosby then drove a fierce free-kick straight at the Seasiders wall, as the half ended in similar style to the opening quarter.
Blackpool found themselves under pressure from the restart and had a lucky escape when referee Moss ignored strong appeals for a penalty when Keogh looked to have been brought down.
However, as the ball flew free Cliff Byrne got the first shot of the match on target, forcing Jones to make a smart stop at his left hand post.
Richard Hinds then fired over the bar before Keogh, who had a brilliant second half, beat two men and rifled in a shot which Jones forced round the post with a brilliant right-handed save.
Sharp, who had looked lively and threatening all afternoon, had the final say when, in the 90th minute, substitute Steve Torpey laid the ball at the striker's feet for him to tap home the winner.