The Republic of Ireland international has not played since January, but made a return for the reserves in midweek.
Josh Lillis has deputised ably during his absence, and will feel he merits keeping his place in the starting line-up.
Despite the return of Murphy, the Iron are troubled by three fresh injury concerns.
Striker Lee Miller and winger Mark Duffy have groin strains, while Marcus Williams has a back injury.
Any hope Garry Thompson had of playing this season has also been ended after he underwent surgery on a groin problem.
Norwich will be without striker Aaron Wilbrahim, who has a back injury.
Midfielder Henri Lansbury, a familiar face to Iron fans, will return for the Canaries following a knock as will defender Zak Whitbread.