Iron wait on captain Byrne
Byrne returned to training during the week having missed last week's win over Colchester with the problem.
The left-back Joseph Mills is also a doubt with a hamstring injury, with Marcus Williams in line to take his place in the starting line-up.
Nigel Adkins has three definite absentees. The on-loan midfielder Liam Trotter is cup-tied having represented Grimsby Town earlier in the competition.
Kenny Milne (knee) and Garry Thompson (Stomach) are also ruled out.
Luton have no injury concerns, although four players are cup-tied.
Mark Bower, Ian Henderson, Kevin Gallen and David Livermore will have to watch from the sidelines on Sunday.
Mark Bower, Ian Henderson, Kevin Gallen and David Livermore will have to watch from the sidelines on Sunday.