The two clubs are seperated by 22 points, with the Diamonds fourth bottom of the League Two table and Scunthorpe seven points clear at the top.
With United unbeaten in their last 10 games - the last seven of which were victories - boss Brian Laws knows the real battle is ensuring his side put in a professional display, knowing that teams often double their efforts to try and beat the top side of the moment.
A win would help write a little piece of Iron history - in their three previous visits to Nene Park they have yet to score a goal.
But with Steve Torpey not facing a three-match ban, as had been feared following an incident at Cambridge last week, and able to continue his fruitful partnership with Paul Hayes this could be the perfect opportunity to set the record straight.
There will be two familiar faces in the home ranks for Iron fans - defender Phil Gulliver had a spell on-loan at Glanford Park last season from Middlesbrough, while striker Craig Dove also had a trial spell with the club.