The Iron are expected to name the same side that drew 1-1 at home to Nottingham Forest last Saturday and equalled a club record for matches undefeated - taking their run to fifteen.
Matt Sparrow looks set to continue on the left flank after an excellent display against Forest, despite competition from Ian Morris and on-loan Kevan Hurst.
Brighton's Dean Hammond will play, despite being told that he needs a hernia operation, as the home team look set to be unchanged as well.
Victory for league leaders Scunthorpe will mean they are one step nearer promotion to the Championship next season.